JAN KOCH - WESER Myocardial Actions of Angiotensin

Myocardial Actions of Angiotensin

• The cardiovascular effects of angiotensin have been studied extensively since its identification 25 years ago." The synthesis of various angiotensins and the demonstration of the pharmacological identity of the naturally occurring and the synthetic octapeptides have facilitated such studies in recent years. It has been found consistently that angiotensin is a powerful constrictor of arteriola...

Nature of the Inotropic Action of Angiotensin on Ventricular Myocardium

• Angiotensin u has a significant positive inotropic action on mammalian ventricular myocardium. In the intact circulation this action is modified or masked by the vascular effects of angiotensin which lead to coronary vasoconstriction and to marked increases of total peripheral resistance. '~ On the other hand, when myocardial contractility is determined directly and when secondary effects of ...

Beta-receptor blockade and myocardial effects of cardiac glycosides.

Nature of the Inotropic Action of Angiotensin on Ventricular Myocardium.

• Angiotensin u has a significant positive inotropic action on mammalian ventricular myocardium. In the intact circulation this action is modified or masked by the vascular effects of angiotensin which lead to coronary vasoconstriction and to marked increases of total peripheral resistance. '~ On the other hand, when myocardial contractility is determined directly and when secondary effects of ...

Myocardial Contraction Frequency and Onset of Cardiac Glycoside Action

Left atrial strips and right ventricular papillary muscles of kittens and left atrial strips of guinea pigs, rabbits, dogs, and chickens were exposed to ouabain, acetylstrophanthidin, or digoxin at 37°C during rest or while contracting at frequencies from 0.06 to 60/min. Both the positive inotropic effect and increases in resting tension developed fully in all preparations exposed to the three ...